Download e-book for iPad: Antithrombotic Drug Therapy in Cardiovascular Disease by Edward F. Plow PHD, Peter Kelly MD (auth.), Arman T. Askari,

By Edward F. Plow PHD, Peter Kelly MD (auth.), Arman T. Askari, A. Michael Lincoff (eds.)

ISBN-10: 1603272348

ISBN-13: 9781603272346

Substantial morbidity and mortality is still linked to thrombotic occasions has encouraged the swift enlargement of the to be had armamentarium to strive against pathologic thrombosis. Pathologic thrombosis performs a vital function within the pathogenesis of acute coronary syndromes (ACS), ischemic problems of percutaneous coronary intervention (PCI), venous thromboembolic ailment, and embolic issues of arrhythmias and numerous cardiomyopathies. Written by way of specialists within the box, Antithrombotic Drug remedy in Cardiovascular Disease conscientiously examines person and diverse mixtures of the on hand antithrombotic regimens together with fibrinolytic brokers, antiplatelet cures (aspirin, thieneopyridines, glycoprotein IIb/IIIa inhibitors), and anticogulant treatments (unfractionated heparin, low-molecular-weight heparins, direct thrombin inhibitors, and artificial issue X inhibitors), non-ST-segment elevation (NSTE) ACS and ST-segment elevation myocardial infarction (STEMI). an in depth evaluate, Antithrombotic Drug treatment in Cardiovascular Disease offers the facts demonstrating the efficacy of accessible antithrombotic remedies in particular affliction states equivalent to atrial traumatic inflammation, cardiomyopathy, valvular center disorder, and heparin-induced thrombocytopenia (HIT).

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Mann KG, van’t Veer C, Cawthern K, Butenas S (1998) The role of the tissue factor pathway in initiation of coagulation. Blood Coagul Fibrinolysis 9:S3–S7 36. Fleck RA, Rao LVM, Rapaport SI, Varki N (1990) Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody. Thromb Res 57:765–781 37. Osterud B (1998) Tissue factor expression by monocytes: regulation and pathophysiological roles. Blood Coagul Fibrinolysis 9(Suppl 1):9–14 38.

Vasc Med 1:275–280 107. Rees DC, Cox M, Clegg JB (1995) World distribution of factor V Leiden. Lancet 345:1133–1134 108. Bertina RM (1997) Factor V Leiden and other coagulation risk factor mutations affecting thrombotic risk. Clin Chem 43:1678–1683 Antithrombotic Drug Therapy in Cardiology: The Role of Coagulation in Arterial and Venous Thrombosis 37 109. Segers K, Dahlback B, Nicolaes GA (2007) Coagulation factor V and thrombophilia: Background and mechanisms. Thromb Haemost 98:530–542 110. Bertina RM (1999) Molecular risk factors for thrombosis.

Despite single case reports, prospective studies have not shown an association between deficiency of antithrombin, protein C, or protein S and MI (142). Antithrombotic Drug Therapy in Cardiology: The Role of Coagulation in Arterial and Venous Thrombosis 33 SUMMARY The coagulation proteins have a vital role in the hemostatic process, defending the body from exsanguination during trauma. However, it is clear that dysregulation of the coagulation system can variously lead to venous thrombosis and contribute to the development of arterial atherothrombotic disease.

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Antithrombotic Drug Therapy in Cardiovascular Disease by Edward F. Plow PHD, Peter Kelly MD (auth.), Arman T. Askari, A. Michael Lincoff (eds.)

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