M. Ian Phillips (auth.), M. Ian Phillips PhD, DSc (eds.)'s Antisense Therapeutics PDF

By M. Ian Phillips (auth.), M. Ian Phillips PhD, DSc (eds.)

ISBN-10: 1588292053

ISBN-13: 9781588292056

ISBN-10: 1592598544

ISBN-13: 9781592598540

Announcement of the whole sequencing of the human genome in April 2003 validated the presence of hundreds of thousands of ambitions for antisense oligonucleotides and opened find out how to 1000's of preclinical animal reviews and a few 20 ongoing scientific trials. during this moment version of Antisense Therapeutics, a workforce of major researchers and scientific scientists show the recent fact of antisense and RNA inhibition for treating a huge variety of ailments. The authors convey how antisense oligonucleotides are being designed and studied in terms of high blood pressure, numerous cancers, inflammatory bowel ailment, mind issues, the blood-brain barrier, and drug supply. Highlights contain RNA-based remedies for lots of illnesses, updated tools and functions, and perception into the big strength to supply a brand new new release of gear.
hugely sensible and illness orientated, Antisense Therapeutics, moment version bargains not just a primer for a brand new iteration of drug discovery researchers, but additionally an illuminating exploration of the aptitude in exploiting RNA inhibition for novel human therapeutics.

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V. (2003) Interference of hepatitis C virus RNA replication by short interfering RNAs. Proc. Natl. Acad. Sci. USA 100, 2014–2018. 72. , and Rice, C. M. (2003) Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs. Proc. Natl. Acad. Sci. USA 100, 235–240. 73. 73 Seo, M. , and Han, J. H. (2003) Small interfering RNA-mediated inhibition of hepatitis C virus replication in the human hepatoma cell line Huh-7. J. Virol. 77, 810–812. 74. 74 McCaffrey, A. , Pham, T.

J. Med. 326, 10–16. 3. 3 King, S. , Lembo, N. , and Weintraub, W. S. (1994) A randomized trial comparing coronary angioplasty with coronary bypass surgery. Emory Angioplasty versus Surgery Trial (EAST). N. Engl. J. Med. 331, 1044–1050. 4. , Mannion, J. , et al. (1998) Synthetic DNA-based compounds for the prevention of coronary restenosis: current status and future challenges. ), Marcel Dekker New York, pp. 363–393. 5. , Kutryk, M. J. , et al. (1998) Antisense oligonucleotide against c-myc administered with the Transport delivery catheter for the prevention of in-stent restenosis: results of the randomized ITALICS trial.

32. 32 Young, K. , and Grasby, J. A. (1997) Metal ions play a passive role in the hairpin ribozyme catalyzed reaction. Nucleic Acids Res. 25, 3760–3766. 30 Zhang et al. 33. 33 Li, Y. and Breaker, R. R. (1999) Deoxyribozymes: new players in the ancient game of biocatalysis. Curr. Opin. Struct. Biol. 9, 315–323. 34. 34 Riddell, S. , Lewinsohn, D. , et al. (1996) T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV infected patients. Nat. Med. 2, 216–223. 35. Taylor, M.

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Antisense Therapeutics by M. Ian Phillips (auth.), M. Ian Phillips PhD, DSc (eds.)

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