By Lionel Fry
Thoroughly revised, this moment variation is an entire replace of the the world over acclaimed first variation of An Atlas of Psoriasis, written by means of Lionel Fry, one of many world's such a lot uncommon dermatologists. Copiously illustrated in colour, together with new prime quality visible imagery only in the near past to be had, the atlas is designed to exchange the outdated version at the cabinets of dermatologists and dermatopathologists around the world. just like the past variation, the e-book offers an authoritative evaluate of psoriasis, together with medical beneficial properties, websites and scientific styles, differential prognosis, psoriatic arthropathy, and therapy.
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Additional info for An Atlas of Psoriasis, Second Edition
It is a very persistent condition; the lesions cleared in only one-third of patients in a 10-year follow-up study. 44 The relationship of localized pustular psoriasis to other forms of psoriasis is still unsettled. In favor of the localized palmar/plantar lesions being a form of psoriasis is the higher incidence of plaque psoriasis in patients with localized pustular psoriasis, compared to a control population. However, there is no reported increase of the HLA antigens, B13, B17, CW6 and DR7 in localized pustular psoriasis.
If the disease is active, the plaques will merge to form large confluent areas of psoriasis (Figures 39–43). The commonest sites for psoriasis are the extensor surfaces of the elbows (Figures 27 and 28), knees (Figures 29 and 30) and scalp, but the skin on any part of the body may be involved, either with or without lesions elsewhere. Another common site is over the sacrum (Figures 44 and 45). The face is the site least likely to be involved. The disease presents as symmetrical welldemarcated red scaly plaques (Figures 27–30).
The system does not rely on the recognition of specific peptides of organisms, as does the more sophisticated so-called adaptive immune system. The innate immune system relies on a set of receptors on cell surfaces that recognize highly conserved microbial motifs (pathogen-associated molecular patterns (PAMPs)). The receptors on the mammalian cells are known as Toll-like receptors (TLRs) and eight of the ten recognize bacterial motifs. TLR-2 recognizes peptidoglycan from Gram-positive bacteria.
An Atlas of Psoriasis, Second Edition by Lionel Fry